Selected Publications

2024

Parakkatel, Dixy; Ruprecht, Nico; von Tengg-Kobligk, Hendrik; Engelhardt, Britta; Heverhagen, Johannes (June 2024). Investigating the role of peripheral blood mononuclear cells in gadolinium deposition in the brain (Unpublished). In: Swiss Congress of Radiology 2024 (SCR'24). Geneva. June 2024.

Berve, Kristina; Michel, Julia; Tietz, Silvia; Blatti, Claudia; Ivan, Daniela; Enzmann, Gaby; Lyck, Ruth; Deutsch, Urban; Locatelli, Giuseppe; Engelhardt, Britta (2024). Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis. European journal of immunology, 54(6), e2350761. Wiley-VCH 10.1002/eji.202350761

Fernandez-Rojo, Manuel A; Pearen, Michael A; Burgess, Anita G; Ikonomopoulou, Maria P; Hoang-Le, Diem; Genz, Berit; Saggiomo, Silvia L; Nawaratna, Sujeevi S K; Poli, Maura; Reissmann, Regina; Gobert, Geoffrey N; Deutsch, Urban; Engelhardt, Britta; Brooks, Andrew J; Jones, Alun; Arosio, Paolo; Ramm, Grant A (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science signaling, 17(830) American Association for the Advancement of Science 10.1126/scisignal.ade4335

Hansen, Cathrin E; Kamermans, Alwin; Mol, Kevin; Berve, Kristina; Rodriguez-Mogeda, Carla; Fung, Wing Ka; van Het Hof, Bert; Fontijn, Ruud D; van der Pol, Susanne M A; Michalick, Laura; Kuebler, Wolfgang M; Kenkhuis, Boyd; van Roon-Mom, Willeke; Liedtke, Wolfgang; Engelhardt, Britta; Kooij, Gijs; Witte, Maarten E; de Vries, Helga E (2024). Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis. Journal of neuroinflammation, 21(72) BioMed Central 10.1186/s12974-024-03069-9

Denes, Adam; Hansen, Cathrin E; Oezorhan, Uemit; Figuerola, Sara; de Vries, Helga E; Sorokin, Lydia; Planas, Anna M; Engelhardt, Britta; Schwaninger, Markus (2024). Endothelial cells and macrophages as allies in the healthy and diseased brain. Acta neuropathologica, 147(38) Springer-Verlag 10.1007/s00401-024-02695-0

McCloskey, Molly C; Kasap, Pelin; Trempel, Michelle; Widom, Louis P; Kuebel, Julia; Chen, Kaihua; Gaborski, Thomas R; Engelhardt, Britta; McGrath, James L (2024). Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier. Journal of visualized experiments(203) MYJoVE Corporation 10.3791/65258

2023

Johann, Lisa; Soldati, Sasha; Müller, Kristin; Lampe, Josephine; Marini, Federico; Klein, Matthias; Schramm, Eva; Ries, Nathalie; Schelmbauer, Carsten; Palagi, Ilaria; Karram, Khalad; Assmann, Julian C; Khan, Mahtab A; Wenzel, Jan; Schmidt, Mirko Hh; Körbelin, Jakob; Schlüter, Dirk; van Loo, Geert; Bopp, Tobias; Engelhardt, Britta; ... (2023). A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS. The journal of clinical investigation, 133(24) American Society for Clinical Investigation 10.1172/JCI168314

Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa; Vanlandewijck, Michael; Muhl, Lars; Mocci, Giuseppe; Bjørnholm, Katrine D; Lindblad, Caroline; Fletcher-Sandersjöö, Alexander; Svensson, Mikael; Thelin, Eric P; Liu, Jianping; van Voorden, A Jantine; Torres, Monica; Antila, Salli; Xin, Li; Karlström, Helena; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; ... (2023). Molecular anatomy of adult mouse leptomeninges. Neuron, 111(23), 3745-3764.e7. Elsevier 10.1016/j.neuron.2023.09.002

Stüdle, Chiara; Nishihara, Hideaki; Wischnewski, Sven; Kulsvehagen, Laila; Perriot, Sylvain; Ishikawa, Hiroshi; Schroten, Horst; Frank, Stephan; Deigendesch, Nikolaus; Du Pasquier, Renaud; Schirmer, Lucas; Pröbstel, Anne-Katrin; Engelhardt, Britta (2023). SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier. Fluids and barriers of the CNS, 20(1), p. 76. BioMed Central 10.1186/s12987-023-00479-4

Saltarin, Federico; Wegmüller, Adrian; Bejarano, Leire; Ildiz, Eco Su; Zwicky, Pascale; Vianin, Andréj; Spadin, Florentin; Soukup, Klara; Wischnewski, Vladimir; Engelhardt, Britta; Deutsch, Urban; Marques, Ines J.; Frenz, Martin; Joyce, Johanna A.; Lyck, Ruth (2023). Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation. Cancers, 15(20), p. 5071. MDPI AG 10.3390/cancers15205071

Mapunda, Josephine A; Pareja, Javier; Vladymyrov, Mykhailo; Bouillet, Elisa; Hélie, Pauline; Pleskač, Petr; Barcos, Sara; Andrae, Johanna; Vestweber, Dietmar; McDonald, Donald M; Betsholtz, Christer; Deutsch, Urban; Proulx, Steven T; Engelhardt, Britta (2023). VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation. Nature communications, 14(1), p. 5837. Nature Publishing Group 10.1038/s41467-023-41580-4

Lyck, Ruth; Nishihara, Hideaki; Aydin, Sidar; Soldati, Sasha; Engelhardt, Britta (2023). Modeling Brain Vasculature Immune Interactions In Vitro. Cold Spring Harbor perspectives in medicine, 13(9), a041185. Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a041185

Lazarevic, Ivana; Soldati, Sasha; Mapunda, Josephine A; Rudolph, Henriette; Rosito, Maria; de Oliveira, Alex Cardoso; Enzmann, Gaby; Nishihara, Hideaki; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Engelhardt, Britta (2023). Correction to: The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids and barriers of the CNS, 20(1), p. 55. BioMed Central 10.1186/s12987-023-00457-w

Gonzalez-Fierro, Carmen; Fonte, Coralie; Dufourd, Eloïse; Cazaentre, Vincent; Aydin, Sidar; Engelhardt, Britta; Caspi, Rachel R; Xu, Biying; Martin-Blondel, Guillaume; Spicer, Julie A; Trapani, Joseph A; Bauer, Jan; Liblau, Roland S; Bost, Chloé (2023). Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation. Neurology: Neuroimmunology and Neuroinflammation, 10(4) Wolters Kluwer Health 10.1212/NXI.0000000000200117

Lazarevic, Ivana; Soldati, Sasha; Mapunda, Josephine A; Rudolph, Henriette; Rosito, Maria; Cardoso de Oliveira, Alex; Enzmann, Gaby; Nishihara, Hideaki; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Engelhardt, Britta (2023). The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids and barriers of the CNS, 20(1), p. 39. BioMed Central 10.1186/s12987-023-00441-4

Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta (2023). Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown. Nature communications, 14(1), p. 3106. Nature Publishing Group 10.1038/s41467-023-38703-2

Soldati, Sasha; Bär, Alexander; Vladymyrov, Mykhailo; Glavin, Dale; McGrath, James L; Gosselet, Fabien; Nishihara, Hideaki; Goelz, Susan; Engelhardt, Britta (2023). High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro. Journal of neuroinflammation, 20(1), p. 123. BioMed Central 10.1186/s12974-023-02797-8

Matsuo, Kinya; Engelhardt, Britta; Nishihara, Hideaki (2023). Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype. Journal of visualized experiments(195) MYJoVE Corporation 10.3791/65134

Spera, Irene; Cousin, Nikola; Ries, Miriam; Kedracka, Anna; Castillo, Alina; Aleandri, Simone; Vladymyrov, Mykhailo; Mapunda, Josephine A; Engelhardt, Britta; Luciani, Paola; Detmar, Michael; Proulx, Steven T (2023). Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. EBioMedicine, 91(104558), p. 104558. Elsevier 10.1016/j.ebiom.2023.104558

Li, Zhilin; Antila, Salli; Nurmi, Harri; Chilov, Dmitri; Korhonen, Emilia A; Fang, Shentong; Karaman, Sinem; Engelhardt, Britta; Alitalo, Kari (2023). Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation. Science immunology, 8(82), eabq0375. American Association for the Advancement of Science 10.1126/sciimmunol.abq0375

C Ivan, Daniela; Berve, Kristina Carolin; Walthert, Sabrina; Monaco, Gianni; Borst, Katharina; Bouillet, Elisa; Ferreira, Filipa; Lee, Henry; Steudler, Jasmin; Buch, Thorsten; Prinz, Marco; Engelhardt, Britta; Locatelli, Giuseppe (2023). Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation. Acta neuropathologica communications, 11(1), p. 35. 10.1186/s40478-023-01535-8

Proulx, Steven T; Engelhardt, Britta (2023). Macrophages clear the way for CNS fluid flow. The lancet. Neurology, 22(3), pp. 194-195. Elsevier 10.1016/S1474-4422(23)00028-5

van Os, Lisette; Engelhardt, Britta; Guenat, Olivier T. (2023). Integration of immune cells in organs-on-chips: a tutorial. Frontiers in Bioengineering and Biotechnology, 11, p. 1191104. Frontiers Media 10.3389/fbioe.2023.1191104

2022

Nishihara, Hideaki; Perriot, Sylvain; Gastfriend, Benjamin D; Steinfort, Marel; Cibien, Celine; Soldati, Sasha; Matsuo, Kinya; Guimbal, Sarah; Mathias, Amandine; Palecek, Sean P; Shusta, Eric V; Du Pasquier, Renaud; Engelhardt, Britta (2022). Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain : a journal of neurology, 145(12), pp. 4334-4348. Oxford University Press 10.1093/brain/awac019

Bagatella, Stefano; Haghayegh Jahromi, Neda; Monney, Camille; Polidori, Margherita; Gall, Flavio Max; Marchionatti, Emma; Serra, Fabienne; Riedl, Rainer; Engelhardt, Britta; Oevermann, Anna (2022). Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors. Journal of neuroinflammation, 19(1), p. 304. BioMed Central 10.1186/s12974-022-02653-1

Ineichen, Benjamin V; Okar, Serhat V; Proulx, Steven T; Engelhardt, Britta; Lassmann, Hans; Reich, Daniel S (2022). Perivascular spaces and their role in neuroinflammation. Neuron, 110(21), pp. 3566-3581. Cell Press 10.1016/j.neuron.2022.10.024

Steudler, Jasmin; Ecott, Timothy; Ivan, Daniela C; Bouillet, Elisa; Walthert, Sabrina; Berve, Kristina; Dick, Tobias P; Engelhardt, Britta; Locatelli, Giuseppe (2022). Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes. GLIA, 70(11), pp. 2045-2061. Wiley-Blackwell 10.1002/glia.24235

Carare, Roxana O; Engelhardt, Britta; Perry, Victor Hugh; Kalaria, Raj (2022). In memoriam, Roy Weller (1938-2022). Acta neuropathologica, 144(5), pp. 803-806. Springer-Verlag 10.1007/s00401-022-02502-8

Kemble, Alicia M; Hornsperger, Benoit; Ruf, Iris; Richter, Hans; Benz, Jörg; Kuhn, Bernd; Heer, Dominik; Wittwer, Matthias; Engelhardt, Britta; Grether, Uwe; Collin, Ludovic (2022). A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. PLoS ONE, 17(9), e0268590. Public Library of Science 10.1371/journal.pone.0268590

Lorusso, Girieca; Wyss, Christof B; Kuonen, François; Vannini, Nicola; Billottet, Clotilde; Duffey, Nathalie; Pineau, Raphael; Lan, Qiang; Wirapati, Pratyaksha; Barras, David; Tancredi, Alessandro; Lyck, Ruth; Lehr, Hans-Anton; Engelhardt, Britta; Delorenzi, Mauro; Bikfalvi, Andreas; Rüegg, Curzio (2022). Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation. Science translational medicine, 14(661), eaax8933. American Association for the Advancement of Science 10.1126/scitranslmed.aax8933

McCloskey, Molly C; Kasap, Pelin; Ahmad, S Danial; Su, Shiuan-Haur; Chen, Kaihua; Mansouri, Mehran; Ramesh, Natalie; Nishihara, Hideaki; Belyaev, Yury; Abhyankar, Vinay V; Begolo, Stefano; Singer, Benjamin H; Webb, Kevin F; Kurabayashi, Katsuo; Flax, Jonathan; Waugh, Richard E; Engelhardt, Britta; McGrath, James L (2022). The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro. Advanced healthcare materials, 11(18), e2200804. Wiley 10.1002/adhm.202200804

Proulx, Steven T.; Engelhardt, Britta (2022). Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance. Journal of internal medicine, 292(1), pp. 47-67. Wiley 10.1111/joim.13469

Cousins, Oliver; Hodges, Angela; Schubert, Julia; Veronese, Mattia; Turkheimer, Federico; Miyan, Jaleel; Engelhardt, Britta; Roncaroli, Federico (2022). The Blood-CSF-Brain Route of Neurological Disease: The Indirect Pathway into the Brain. Neuropathology and applied neurobiology, 48(4), e12789. Wiley 10.1111/nan.12789

Engelhardt, Britta; Comabella, Manuel; Chan, Andrew (2022). Multiple Sclerosis: Immunopathological heterogeneity and its implications. European journal of immunology, 52(6), pp. 869-881. Wiley-VCH 10.1002/eji.202149757

Holder, Brianna M; Tolan, Shaina E; Heinrich, Kaleb K; Miller, Kaitlin C; Hudson, Natalie; Nehra, Geetika; Pizzo, Michelle E; Storck, Steffen E; Elmquist, William F; Engelhardt, Britta; Loryan, Irena; Toborek, Michal; Bauer, Bjoern; Hartz, Anika M S; Kim, Brandon J (2022). Brain barriers virtual: an interim solution or future opportunity? Fluids and barriers of the CNS, 19(1), p. 19. BioMed Central 10.1186/s12987-022-00314-2

Mapunda, Josephine A; Tibar, Houyam; Regragui, Wafa; Engelhardt, Britta (2022). How Does the Immune System Enter the Brain? Frontiers in immunology, 13(805657), p. 805657. Frontiers Research Foundation 10.3389/fimmu.2022.805657

Martinez-Salazar, Maria; Holwerda, Melle; Stüdle, Chiara; Piragyte, Indre; Mercader, Nadia; Engelhardt, Britta; Rieben, Robert; Döring, Yvonne (2022). COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences. Frontiers in cell and developmental biology, 10, p. 824851. Frontiers 10.3389/fcell.2022.824851

Marchetti, Luca; Francisco, David; Soldati, Sasha; Haghayegh Jahromi, Neda; Barcos, Sara; Gruber, Isabelle; Pareja R., Javier; Thiriot, Aude; von Andrian, Ulrich; Deutsch, Urban; Lyck, Ruth; Bruggmann, Rémy; Engelhardt, Britta (2022). ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. European journal of immunology, 52(1), pp. 161-177. Wiley 10.1002/eji.202149238

Nishihara, Hideaki; Engelhardt, Britta (2022). Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective. Handbook of experimental pharmacology, 273, pp. 295-329. Springer 10.1007/164_2020_407

Galoppin, Manon; Kari, Saniya; Soldati, Sasha; Pal, Arindam; Rival, Manon; Engelhardt, Britta; Astier, Anne; Thouvenot, Eric (2022). Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications. Brain Communications, 4(4), fcac171. Oxford University Press 10.1093/braincomms/fcac171

2021

Gastfriend, Benjamin D; Nishihara, Hideaki; Canfield, Scott G; Foreman, Koji L; Engelhardt, Britta; Palecek, Sean P; Shusta, Eric V (2021). Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells. eLife, 10 eLife Sciences Publications 10.7554/eLife.70992

Thomsen, Tanja; Reissmann, Regina; Kaba, Elisa; Engelhardt, Britta; Klok, Harm-Anton (2021). Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes. Biomacromolecules, 22(8), pp. 3416-3430. American Chemical Society 10.1021/acs.biomac.1c00488

Engelhardt, Britta (2021). Private immune protection at the border of the central nervous system. Nature, 596(7870), pp. 38-40. Springer Nature 10.1038/d41586-021-01962-4

Nishihara, Hideaki; Gastfriend, Benjamin D; Kasap, Pelin; Palecek, Sean P; Shusta, Eric V; Engelhardt, Britta (2021). Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions. STAR protocols, 2(2), p. 100563. Elsevier 10.1016/j.xpro.2021.100563

Derada Troletti, Claudio; Enzmann, Gaby; Chiurchiù, Valerio; Kamermans, Alwin; Tietz, Silvia Martina; Norris, Paul C; Haghayegh Jahromi, Neda; Leuti, Alessandro; van der Pol, Susanne M A; Schouten, Marijn; Serhan, Charles N; de Vries, Helga E; Engelhardt, Britta; Kooij, Gijs (2021). Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell reports, 35(9), p. 109201. Cell Press 10.1016/j.celrep.2021.109201

Hamminger, Patricia; Marchetti, Luca; Preglej, Teresa; Platzer, René; Zhu, Ci; Kamnev, Anton; Rica, Ramona; Stolz, Valentina; Sandner, Lisa; Alteneder, Marlis; Kaba, Elisa; Waltenberger, Darina; Huppa, Johannes B; Trauner, Michael; Bock, Christoph; Lyck, Ruth; Bauer, Jan; Dupré, Loïc; Seiser, Christian; Boucheron, Nicole; ... (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. Journal of autoimmunity, 119, p. 102610. Elsevier 10.1016/j.jaut.2021.102610

Baier, Felix Alexander; Sánchez-Taltavull, Daniel; Yarahmadov, Tural; Castellà, Cristina Gómez; Jebbawi, Fadi; Keogh, Adrian; Tombolini, Riccardo; Odriozola, Adolfo; Castro Dias, Mariana; Deutsch, Urban; Furuse, Mikio; Engelhardt, Britta; Zuber, Benoît; Odermatt, Alex; Candinas, Daniel; Keogh-Stroka, Deborah M. (2021). Loss of claudin-3 impairs hepatic metabolism, biliary barrier function and cell proliferation in the murine liver. Cellular and molecular gastroenterology and hepatology, 12(2), pp. 745-767. Elsevier 10.1016/j.jcmgh.2021.04.003

Reynoso-Moreno, Ines; Tietz, Silvia; Vallini, Erika; Engelhardt, Britta; Gertsch, Jürg; Chicca, Andrea (2021). Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis. ACS pharmacology & translational science, 4(2), pp. 765-779. ACS Publications 10.1021/acsptsci.0c00214

Ayer, Maxime; Burri, Olivier; Guiet, Romain; Seitz, Arne; Kaba, Elisa; Engelhardt, Britta; Klok, Harm-Anton (2021). Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes. Bioconjugate chemistry, 32(3), pp. 541-552. American Chemical Society 10.1021/acs.bioconjchem.1c00026

Imeri, Faik; Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Enzmann, Gaby; Schwalm, Stephanie; Pfeilschifter, Josef; Homann, Thomas; Kleuser, Burkhard; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2021). Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 186, p. 108464. Elsevier 10.1016/j.neuropharm.2021.108464

Ayer, Maxime; Schuster, Markus; Gruber, Isabelle; Blatti, Claudia; Kaba, Elisa; Enzmann, Gaby; Burri, Olivier; Guiet, Romain; Seitz, Arne; Engelhardt, Britta; Klok, Harm-Anton (2021). T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier. Advanced healthcare materials, 10(2), e2001375. Wiley 10.1002/adhm.202001375

Castro Dias, Mariana; Odriozola Quesada, Adolfo; Soldati, Sasha; Bösch, Fabio; Gruber, Isabelle; Hildbrand, Tobias; Sönmez, Derya; Khire, Tejas; Witz, Guillaume; McGrath, James L.; Piontek, Jörg; Kondoh, Masuo; Deutsch, Urban; Zuber, Benoît; Engelhardt, Britta (2021). Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier. Journal of cell science, 134(8) Company of Biologists Limited 10.1242/jcs.253880

Sasson, Esther; Anzi, Shira; Bell, Batia; Yakovian, Oren; Zorsky, Meshi; Deutsch, Urban; Engelhardt, Britta; Sherman, Eilon; Vatine, Gad; Dzikowski, Ron; Ben-Zvi, Ayal (2021). Nano-scale architecture of blood-brain barrier tight-junctions. eLife, 10 eLife Sciences Publications 10.7554/eLife.63253

2020

Nishihara, Hideaki; Gastfriend, Benjamin D; Soldati, Sasha; Perriot, Sylvain; Mathias, Amandine; Sano, Yasuteru; Shimizu, Fumitaka; Gosselet, Fabien; Kanda, Takashi; Palecek, Sean P; Du Pasquier, Renaud; Shusta, Eric V; Engelhardt, Britta (2020). Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB journal, 34(12), pp. 16693-16715. Federation of American Societies for Experimental Biology 10.1096/fj.202001507RR

Locatelli, Giuseppe; Engelhardt, Britta (2020). Microglia Get a Little Help from "Th"-eir Friends. Immunity, 53(3), pp. 484-486. Cell Press 10.1016/j.immuni.2020.08.011

Stepanovska, Bisera; Zivkovic, Aleksandra; Enzmann, Gaby; Tietz, Silvia; Homann, Thomas; Kleuser, Burkhard; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2020). Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis. International journal of molecular sciences, 21(18), pp. 1-17. MDPI 10.3390/ijms21186463

Francisco, David M F; Marchetti, Luca; Rodríguez-Lorenzo, Sabela; Frías-Anaya, Eduardo; Figueiredo, Ricardo M; Winter, Peter; Romero, Ignacio Andres; de Vries, Helga E; Engelhardt, Britta; Bruggmann, Rémy (2020). Advancing brain barriers RNA sequencing: guidelines from experimental design to publication. Fluids and barriers of the CNS, 17(1), p. 51. BioMed Central 10.1186/s12987-020-00207-2

Heymans, Marjolein; Figueiredo, Ricardo; Dehouck, Lucie; Francisco, David; Sano, Yasuteru; Shimizu, Fumitaka; Kanda, Takashi; Bruggmann, Rémy; Engelhardt, Britta; Winter, Peter; Gosselet, Fabien; Culot, Maxime (2020). Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells. Fluids and barriers of the CNS, 17(1), p. 48. BioMed Central 10.1186/s12987-020-00208-1

Bruggisser, Julia; Tarek, Basma; Wyder, Marianne; Müller, Philipp; von Ballmoos, Christoph; Witz, Guillaume; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta; Posthaus, Horst (2020). CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell host & microbe, 28(1), pp. 69-78. Cell Press 10.1016/j.chom.2020.05.003

Hahn, Julia; Günter, Manina; Schuhmacher, Juliane; Bieber, Kristin; Pöschel, Simone; Schütz, Monika; Engelhardt, Britta; Oster, Henrik; Sina, Christian; Lange, Tanja; Autenrieth, Stella E (2020). Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice. Brain, behavior, and immunity, 87, pp. 329-338. Elsevier 10.1016/j.bbi.2020.01.001

Li, Zhilin; Korhonen, Emilia A; Merlini, Arianna; Strauss, Judith; Wihuri, Eleonoora; Nurmi, Harri; Antila, Salli; Paech, Jennifer; Deutsch, Urban; Engelhardt, Britta; Chintharlapalli, Sudhakar; Koh, Gou Young; Flügel, Alexander; Alitalo, Kari (2020). Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS. The journal of clinical investigation, 130(4), pp. 1977-1990. American Society for Clinical Investigation 10.1172/JCI130308

Marchetti, Luca; Engelhardt, Britta (2020). Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation. Vascular biology (Bristol, England), 2(1), H1-H18. 10.1530/VB-19-0033

Nishihara, Hideaki; Soldati, Sasha; Mossu, Adrien; Rosito, Maria; Rudolph, Henriette; Muller, William A; Latorre, Daniela; Sallusto, Federica; Sospedra, Mireia; Martin, Roland; Ishikawa, Hiroshi; Tenenbaum, Tobias; Schroten, Horst; Gosselet, Fabien; Engelhardt, Britta (2020). Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro. Fluids and barriers of the CNS, 17(1), p. 3. BioMed Central 10.1186/s12987-019-0165-2

Haghayegh Jahromi, Neda; Marchetti, Luca; Moalli, Federica; Duc, Donovan; Basso, Camilla; Tardent, Heidi; Kaba, Elisa; Deutsch, Urban; Pot, Caroline; Sallusto, Federica; Stein, Jens V.; Engelhardt, Britta (2020). Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 10(3056), p. 3056. Frontiers Research Foundation 10.3389/fimmu.2019.03056

Thiele née Schrewe, Lisa; Guse, Kirsten; Tietz, Silvia; Remlinger, Jana; Demir, Seray; Pedreiturria, Xiomara; Hoepner, Robert; Salmen, Anke; Pistor, Maximilian; Turner, Timothy; Engelhardt, Britta; Hermann, Dirk M; Lühder, Fred; Wiese, Stefan; Chan, Andrew (2020). Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis. Journal of neuroinflammation, 17(1), p. 9. BioMed Central 10.1186/s12974-019-1677-z

Hlushchuk, Ruslan; Haberthür, David; Soukup, Petr; Barré, Sebastien F.; Khoma, Oleksiy-Zakhar; Schittny, Johannes; Haghayegh Jahromi, Neda; Bouchet, Audrey; Engelhardt, Britta; Djonov, Valentin Georgiev (2020). Innovative high-resolution microCT imaging of animal brain vasculature. Brain structure & function, 225(9), pp. 2885-2895. Springer 10.1007/s00429-020-02158-8

Gericke, Christoph; Mallone, Anna; Engelhardt, Britta; Nitsch, Roger M; Ferretti, Maria Teresa (2020). Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in immunology, 11, p. 1029. Frontiers Research Foundation 10.3389/fimmu.2020.01029

Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216

Vladymyrov, Mykhailo; Haghayegh Jahromi, Neda; Kaba, Elisa; Engelhardt, Britta; Ariga, Akitaka (2020). VivoFollow 2: Distortion-Free Multiphoton Intravital Imaging. Frontiers in physics, 7 Frontiers Media 10.3389/fphy.2019.00222

Engelhardt, Britta (2020). Maternal Infection Impairs Fetal Brain Development via Choroid Plexus Inflammation. Developmental cell, 55(5), pp. 519-521. Cell Press 10.1016/j.devcel.2020.11.011

2019

Garnier, Arnaud; Laffont, Sophie; Garnier, Laure; Kaba, Elisa; Deutsch, Urban; Engelhardt, Britta; Guéry, Jean-Charles (2019). CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation. European journal of immunology, 49(11), pp. 2030-2043. Wiley-VCH 10.1002/eji.201948086

Castro Dias, Mariana; Mapunda, Josephine A.; Vladymyrov, Mykhailo; Engelhardt, Britta (2019). Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. International journal of molecular sciences, 20(21) MDPI 10.3390/ijms20215372

Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam-Klages, Sabine; Agace, William W; Aghaeepour, Nima; Akdis, Mübeccel; Allez, Matthieu; Almeida, Larissa Nogueira; Alvisi, Giorgia; Anderson, Graham; Andrä, Immanuel; Annunziato, Francesco; Anselmo, Achille; Bacher, Petra; Baldari, Cosima T; Bari, Sudipto; Barnaba, Vincenzo; ... (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European journal of immunology, 49(10), pp. 1457-1973. Wiley-VCH 10.1002/eji.201970107

Castro Dias, Mariana; Coisne, Caroline; Baden, Pascale; Enzmann, Gaby; Garrett, Lillian; Becker, Lore; Hölter, Sabine M; Hrabě de Angelis, Martin; Deutsch, Urban; Engelhardt, Britta (2019). Claudin-12 is not required for blood-brain barrier tight junction function. Fluids and barriers of the CNS, 16(1), p. 30. BioMed Central 10.1186/s12987-019-0150-9

Castro Dias, Mariana; Coisne, Caroline; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Ferreira Francisco, David Miguel; Vanlandewijck, Michael; He, Liqun; Baier, Felix A.; Stroka, Deborah; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta (2019). Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers. Scientific reports, 9(1), p. 10702. Springer Nature 10.1038/s41598-019-43511-0

Tietz, Silvia; Engelhardt, Britta (2019). Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo. Journal of visualized experiments(145) MYJoVE Corporation 10.3791/59249

Enzmann, Gaby; Adelfio, Roberto; Godel, Aurélie; Haghayegh Jahromi, Neda; Tietz, Silvia; Burgener, Sabrina S.; Deutsch, Urban; Wekerle, Hartmut; Benarafa, Charaf; Engelhardt, Britta (2019). The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis. International journal of molecular sciences, 20(6) MDPI 10.3390/ijms20061433

Mota Castro Dias, Mariana; Coisne, Caroline Marie; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Francisco, David Miguel Ferreira; Vanlandewijck, Michael; He, Liqun; Baier, Felix Alexander; Keogh-Stroka, Deborah M.; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta (2019). Claudin-3-deficient C57BL/6J mice display intact brain barriers. Scientific Reports, 9(1), p. 203. Nature Publishing Group 10.1038/s41598-018-36731-3

Mossu, Adrien; Rosito, Maria; Khire, Tejas; Li Chung, Hung; Nishihara, Hideaki; Gruber, Isabelle; Luke, Emma; Dehouck, Lucie; Sallusto, Federica; Gosselet, Fabien; McGrath, James L; Engelhardt, Britta (2019). A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow. Journal of cerebral blood flow and metabolism, 39(3), pp. 395-410. Sage 10.1177/0271678X18820584

Wimmer, Isabella; Tietz, Silvia; Nishihara, Hideaki; Deutsch, Urban; Sallusto, Federica; Gosselet, Fabien; Lyck, Ruth; Muller, William A; Lassmann, Hans; Engelhardt, Britta (2019). PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation. Frontiers in immunology, 10, p. 711. Frontiers Research Foundation 10.3389/fimmu.2019.00711

2018

Enzmann, Gaby; Pavlidou, Sofia; Vaas, Markus; Klohs, Jan; Engelhardt, Britta (2018). ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke. Translational stroke research, 9(6), pp. 608-621. Springer 10.1007/s12975-018-0612-4

Evangelopoulos, Maria Eleftheria; Miclea, Andrei; Schrewe, Lisa; Briner, Myriam; Salmen, Anke; Engelhardt, Britta; Huwiler, Andrea; Chan, Andrew; Hoepner, Robert (2018). Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod. CNS neuroscience & therapeutics, 24(10), pp. 984-986. Wiley 10.1111/cns.12992

Tietz, Silvia; Périnat, Therese; Greene, Gretchen Thompson; Enzmann, Gaby; Deutsch, Urban; Adams, Ralf; Imhof, Beat; Aurrand-Lions, Michel; Engelhardt, Britta (2018). Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis. Brain, behavior, and immunity, 73, pp. 3-20. Elsevier 10.1016/j.bbi.2018.06.014

Roth, Stefan; Singh, Vikramjeet; Tiedt, Steffen; Schindler, Lisa; Huber, Georg; Geerlof, Arie; Antoine, Daniel J; Anfray, Antoine; Orset, Cyrille; Gauberti, Maxime; Fournier, Antoine; Holdt, Lesca M; Harris, Helena Erlandsson; Engelhardt, Britta; Bianchi, Marco E; Vivien, Denis; Haffner, Christof; Bernhagen, Jürgen; Dichgans, Martin and Liesz, Arthur (2018). Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Science translational medicine, 10(432) American Association for the Advancement of Science 10.1126/scitranslmed.aao1313

Engelhardt, Britta (2018). Cluster: barriers of the central nervous system. Acta neuropathologica, 135(3), pp. 307-310. Springer-Verlag 10.1007/s00401-018-1816-0

Ghersi-Egea, Jean-François; Strazielle, Nathalie; Catala, Martin; Silva-Vargas, Violeta; Doetsch, Fiona; Engelhardt, Britta (2018). Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease. Acta neuropathologica, 135(3), pp. 337-361. Springer-Verlag 10.1007/s00401-018-1807-1

Uster, Stephanie Sarah; Matos Coelho, Fernanda; Aeberli, Daniel; Stein, Jens Volker; Hofstetter, Wilhelm; Engelhardt, Britta; Seitz, Michael (2018). TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply. Bone, 107, pp. 56-65. Elsevier 10.1016/j.bone.2017.10.020

Enzmann, Gaby; Kargaran, Soghra; Engelhardt, Britta (2018). Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function. Therapeutic advances in neurological disorders, 11, p. 1756286418794184. Sage 10.1177/1756286418794184

2017

Llovera, Gemma; Benakis, Corinne; Enzmann, Gaby; Cai, Ruiyao; Arzberger, Thomas; Ghasemigharagoz, Alireza; Mao, Xiang; Malik, Rainer; Lazarevic, Ivana; Liebscher, Sabine; Ertürk, Ali; Meissner, Lilja; Vivien, Denis; Haffner, Christof; Plesnila, Nikolaus; Montaner, Joan; Engelhardt, Britta; Liesz, Arthur (2017). The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta neuropathologica, 134(6), pp. 851-868. Springer 10.1007/s00401-017-1758-y

Zaretsky, Irina; Atrakchi, Ofir; Mazor, Roei D; Stoler-Barak, Liat; Biram, Adi; Feigelson, Sara W; Gitlin, Alexander D; Engelhardt, Britta; Shulman, Ziv (2017). ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. The Journal of experimental medicine, 214(11), pp. 3435-3448. Rockefeller Univ. Press 10.1084/jem.20171129

Mathias, Amandine; Perriot, Sylvain; Canales, Mathieu; Blatti, Claudia; Gaubicher, Coline; Schluep, Myriam; Engelhardt, Britta; Du Pasquier, Renaud (2017). Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate. Neurology: Neuroimmunology and Neuroinflammation, 4(6), e401. Wolters Kluwer Health 10.1212/NXI.0000000000000401

Daneman, Richard; Engelhardt, Britta (2017). Brain barriers in health and disease. Neurobiology of disease, 107, pp. 1-3. Elsevier 10.1016/j.nbd.2017.05.008

Vaas, Markus; Enzmann, Gaby; Périnat, Therese; Siler, Ulrich; Reichenbach, Janine; Licha, Kai; Kipar, Anja; Rudin, Markus; Engelhardt, Britta; Klohs, Jan (2017). Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia. Journal of cerebral blood flow and metabolism, 37(8), pp. 2833-2847. Nature Publishing Group 10.1177/0271678X16676825

Lyck, Ruth; Lécuyer, Marc-André; Abadier, Michael Magdy Labib; Wyss, Christof B.; Matti, Christoph; Rosito, Maria; Enzmann, Gaby; Zeis, Thomas; Michel, Laure; García Martín, Ana B; Sallusto, Federica; Gosselet, Fabien; Deutsch, Urban; Weiner, Joshua A.; Schaeren-Wiemers, Nicole; Prat, Alexandres; Engelhardt, Britta (2017). ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier. Journal of cerebral blood flow and metabolism, 37(8), pp. 2894-2909. Nature Publishing Group 10.1177/0271678X16678639

Atangana, Etienne; Schneider, Ulf C; Blecharz, Kinga; Magrini, Salima; Wagner, Josephin; Nieminen-Kelhä, Melina; Kremenetskaia, Irina; Heppner, Frank L; Engelhardt, Britta; Vajkoczy, Peter (2017). Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH). Translational stroke research, 8(2), pp. 144-156. Springer 10.1007/s12975-016-0485-3

Engelhardt, Britta; Vajkoczy, Peter; Weller, Roy O (2017). The movers and shapers in immune privilege of the CNS. Nature immunology, 18(2), pp. 123-131. Nature Publishing Group 10.1038/ni.3666

Lécuyer, Marc-André; Saint-Laurent, Olivia; Bourbonnière, Lyne; Larouche, Sandra; Larochelle, Catherine; Michel, Laure; Charabati, Marc; Abadier, Michael Magdy Labib; Zandee, Stephanie; Haghayegh Jahromi, Neda; Gowing, Elizabeth; Pittet, Camille; Lyck, Ruth; Engelhardt, Britta; Prat, Alexandre (2017). Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(4), E524-E533. National Academy of Sciences NAS 10.1073/pnas.1614336114

Haghayegh Jahromi, Neda; Tardent, Heidi; Enzmann, Gaby; Deutsch, Urban; Kawakami, Naoto; Bittner, Stefan; Vestweber, Dietmar; Zipp, Frauke; Stein, Jens Volker; Engelhardt, Britta (2017). A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 8, p. 406. 10.3389/fimmu.2017.00406

Pavlicek, David; Krebs, Jörg; Capossela, Simona; Bertolo, Alessandro; Engelhardt, Britta; Pannek, Jürgen; Stoyanov, Jivko (2017). Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study. Immunity & ageing, 14(22), p. 22. BioMed Central 10.1186/s12979-017-0103-6

Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Akdis, Mübeccel; Andrä, Immanuel; Annunziato, Francesco; Bacher, Petra; Barnaba, Vincenzo; Battistini, Luca; Bauer, Wolfgang M; Baumgart, Sabine; Becher, Burkhard; Beisker, Wolfgang; Berek, Claudia; Blanco, Alfonso; Borsellino, Giovanna; Boulais, Philip E; Brinkman, Ryan R; Büscher, Martin; Busch, Dirk H; ... (2017). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European journal of immunology, 47(10), pp. 1584-1797. Wiley-VCH 10.1002/eji.201646632

2016

Tietz, Silvia; Zwahlen, Marcel; Haghayegh Jahromi, Neda; Baden, Pascale; Lazarevic, Ivana; Enzmann, Gaby; Engelhardt, Britta (2016). Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences. European journal of immunology, 46(10), pp. 2481-2483. Wiley-VCH 10.1002/eji.201546272

Engelhardt, Britta; Carare, Roxana O; Bechmann, Ingo; Flügel, Alexander; Laman, Jon D; Weller, Roy O (2016). Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta neuropathologica, 132(3), pp. 317-338. Springer 10.1007/s00401-016-1606-5

Martin, Roland; Sospedra, Mireia; Rosito, Maria; Engelhardt, Britta (2016). Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis. European journal of immunology, 46(9), pp. 2078-2090. Wiley-VCH 10.1002/eji.201646485

Rudolph, Henriette; Klopstein, Armelle; Gruber, Isabelle Manuela; Blatti, Claudia; Lyck, Ruth; Engelhardt, Britta (2016). Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro. European journal of immunology, 46(9), pp. 2187-2203. Wiley-VCH 10.1002/eji.201546251

Fan, Zhichao; McArdle, Sara; Marki, Alex; Mikulski, Zbigniew; Gutierrez, Edgar; Engelhardt, Britta; Deutsch, Urban; Ginsberg, Mark; Groisman, Alex; Ley, Klaus (2016). Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis. Nature communications, 7, p. 12658. Nature Publishing Group 10.1038/ncomms12658

Petrovich, Ekaterina; Feigelson, Sara W; Stoler-Barak, Liat; Hatzav, Miki; Solomon, Adam; Bar-Shai, Amir; Ilan, Neta; Li, Jin-Ping; Engelhardt, Britta; Vlodavsky, Israel; Alon, Ronen (2016). Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs. FASEB journal, 30(5), pp. 1767-1778. Federation of American Societies for Experimental Biology 10.1096/fj.201500046

Feretti, MT; Merlini, M; Späni, C; Gericke, C; Schweizer, N; Enzmann, Gaby; Engelhardt, Britta; Kulic, L; Suter, T; Nitsch, RM (2016). T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis. Brain, behavior, and immunity, 54, pp. 211-225. Elsevier 10.1016/j.bbi.2016.02.009

Imeri, Faik; Schwalm, Stephanie; Lyck, Ruth; Zivkovic, Aleksandra; Stark, Holger; Engelhardt, Britta; Pfeilschifter, Josef; Huwiler, Andrea (2016). Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105, pp. 341-350. Elsevier 10.1016/j.neuropharm.2016.01.031

Mundt, Sarah; Engelhardt, Britta; Kirk, Christopher J; Groettrup, Marcus; Basler, Michael (2016). Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. European journal of immunology, 46(1), pp. 104-113. Wiley-VCH 10.1002/eji.201545578

Lopes Pinheiro, Melissa A; Kooij, Gijs; Mizee, Mark R; Kamermans, Alwin; Enzmann, Gaby; Lyck, Ruth; Schwaninger, Markus; Engelhardt, Britta; de Vries, Helga E (2016). Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochimica et biophysica acta - molecular basis of disease, 1862(3), pp. 461-471. Elsevier 10.1016/j.bbadis.2015.10.018

Lazarevic, Ivana; Engelhardt, Britta (2016). Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids and barriers of the CNS, 13(2), p. 2. BioMed Central 10.1186/s12987-016-0027-0

2015

Alonso, Angelika; Eisele, Philipp; Ebert, Anne D; Griebe, Martin; Engelhardt, Britta; Szabo, Kristina; Hennerici, Michael G; Gass, Achim (2015). Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis. Neurology: Neuroimmunology and Neuroinflammation, 2(6), e164. Wolters Kluwer Health 10.1212/NXI.0000000000000164

Martin-Blondel, Guillaume; Pignolet, Béatrice; Tietz, Silvia; Yshii, Lidia; Gebauer, Christina; Périnat, Therese; Van Weddingen, Isabelle; Blatti, Claudia; Engelhardt, Britta; Liblau, Roland (2015). Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin. European journal of immunology, 45(12), pp. 3302-3312. Wiley-VCH 10.1002/eji.201545632

Wälchli, Thomas; Wacker, Andrin; Frei, Karl; Regli, Luca; Schwab, Martin E; Hoerstrup, Simon P; Gerhardt, Holger; Engelhardt, Britta (2015). Wiring the Vascular Network with Neural Cues: A CNS Perspective. Neuron, 87(2), pp. 271-296. Cell Press 10.1016/j.neuron.2015.06.038

Staat, Christian; Coisne, Caroline Marie; Dabrowski, Sebastian; Stamatovic, Svetlana M; Andjelkovic, Anuska V; Wolburg, Hartwig; Engelhardt, Britta; Blasig, Ingolf E (2015). Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers. Biomaterials, 54, pp. 9-20. Elsevier 10.1016/j.biomaterials.2015.03.007

Tietz, Silvia; Engelhardt, Britta (2015). Brain barriers: Crosstalk between complex tight junctions and adherens junctions. Journal of cell biology, 209(4), pp. 493-506. Rockefeller Institute Press 10.1083/jcb.201412147

Eisele, Philipp; Griebe, Martin; Szabo, Kristina; Wolf, Marc E; Alonso, Angelika; Engelhardt, Britta; Hennerici, Michael G; Gass, Achim (2015). Investigation of leptomeningeal enhancement in MS: A postcontrast FLAIR MRI study. Neurology, 84(8), pp. 770-775. Lippincott Williams & Wilkins 10.1212/WNL.0000000000001286

Abadier, Michael Magdy Labib; Haghayegh Jahromi, Neda; Cardoso Alves, Ludmila; Boscacci, Rémy; Vestweber, Dietmar; Barnum, Scott; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth (2015). Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. European journal of immunology, 45(4), pp. 1043-1058. Wiley-VCH 10.1002/eji.201445125

2014

Steiner, Esther; Enzmann, Gaby; Lyck, Ruth; Lin, Shuo; Rüegg, Markus A; Kröger, Stephan; Engelhardt, Britta (2014). The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and tissue research, 358(2), pp. 465-479. Springer 10.1007/s00441-014-1969-7

Imeri, Faik; Fallegger, Daniel; Zivkovic, Aleksandra; Schwalm, Stephanie; Enzmann, Gaby; Blankenbach, Kira; Meyer zu Heringdorf, Dagmar; Homann, Thomas; Kleuser, Burkhard; Pfeilschifter, Josef; Engelhardt, Britta; Stark, Holger; Huwiler, Andrea (2014). Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology, 85, pp. 314-327. Elsevier 10.1016/j.neuropharm.2014.05.012

Aubé, Benoit; Lévesque, Sébastien A; Paré, Alexandre; Chamma, Émilie; Kébir, Hania; Gorina Mendiz, Roser; Lécuyer, Marc-André; Alvarez, Jorge I; De Koninck, Yves; Engelhardt, Britta; Prat, Alexandre; Côté, Daniel; Lacroix, Steve (2014). Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases. Journal of immunology, 193(5), pp. 2438-2454. American Association of Immunologists 10.4049/jimmunol.1400401

Sathiyanadan, Karthik; Coisne, Caroline Marie; Enzmann, Gaby; Deutsch, Urban; Engelhardt, Britta (2014). PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE. European journal of immunology, 44(8), pp. 2287-2294. Wiley-VCH 10.1002/eji.201344214

Engelhardt, Britta; Liebner, Stefan (2014). Novel insights into the development and maintenance of the blood-brain barrier. Cell and tissue research, 355(3), pp. 687-699. Springer 10.1007/s00441-014-1811-2

Gorina Mendiz, Roser; Lyck, Ruth; Vestweber, Dietmar; Engelhardt, Britta (2014). β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. Journal of immunology, 192(1), pp. 324-337. American Association of Immunologists 10.4049/jimmunol.1300858

Cecchelli, Romeo; Aday, Sezin; Sevin, Emmanuel; Almeida, Catarina; Culot, Maxime; Dehouck, Lucie; Coisne, Caroline Marie; Engelhardt, Britta; Dehouck, Marie-Pierre; Ferreira, Lino (2014). A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS ONE, 9(6), e99733. Public Library of Science 10.1371/journal.pone.0099733

Minten, Carsten; Alt, Carsten; Gentner, Melanie; Frei, Elisabeth; Deutsch, Urban; Lyck, Ruth; Schaeren-Wiemers, Nicole; Rot, Antal; Engelhardt, Britta (2014). DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation. Brain, 137(Pt 5), pp. 1454-1469. Oxford University Press 10.1093/brain/awu045

2013

Moretti, Federico A.; Moser, Markus; Lyck, Ruth; Abadier, Michael Magdy Labib; Ruppert, Raphael; Engelhardt, Britta; Fässler, Reinhard (2013). Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 110(42), pp. 17005-17010. National Academy of Sciences NAS 10.1073/pnas.1316032110

Paolinelli, Roberta; Corada, Monica; Ferrarini, Luca; Devraj, Kavi; Artus, Cédric; Czupalla, Cathrin J.; Rudini, Noemi; Maddaluno, Luigi; Papa, Eleanna; Engelhardt, Britta; Couraud, Pierre Olivier; Liebner, Stefan; Dejana, Elisabetta (2013). Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS ONE, 8(8), e70233. Public Library of Science 10.1371/journal.pone.0070233

Enzmann, Gaby; Mysiorek, Caroline; Gorina, Roser; Cheng, Yu-Jung; Ghavampour, Sharang; Hannocks, Melanie-Jane; Prinz, Vincent; Dirnagl, Ulrich; Endres, Matthias; Prinz, Marco; Beschorner, Rudi; Harter, Patrick N.; Mittelbronn, Michel; Engelhardt, Britta; Sorokin, Lydia (2013). The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta neuropathologica, 125(3), pp. 395-412. Berlin: Springer-Verlag 10.1007/s00401-012-1076-3

Coisne, Caroline; Lyck, Ruth; Engelhardt, Britta (2013). Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo. Fluids and barriers of the CNS, 10(1), p. 7. London: BioMed Central

Muldoon, Leslie L; Alvarez, Jorge I; Begley, David J; Boado, Ruben J; Del Zoppo, Gregory J; Doolittle, Nancy D; Engelhardt, Britta; Hallenbeck, John M; Lonser, Russell R; Ohlfest, John R; Prat, Alexandre; Scarpa, Maurizio; Smeyne, Richard J; Drewes, Lester R; Neuwelt, Edward A (2013). Immunologic privilege in the central nervous system and the blood-brain barrier. Journal of cerebral blood flow and metabolism, 33(1), pp. 13-21. New York, N.Y.: Nature Publishing Group 10.1038/jcbfm.2012.153

2012

Kronstein, Romy; Seebach, Jochen; Grossklaus, Sylvia; Minten, Carsten; Engelhardt, Britta; Drab, Marek; Liebner, Stefan; Arsenijevic, Yvan; Taha, Abdallah Abu; Afanasieva, Tatiana; Schnittler, Hans-Joachim (2012). Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovascular research, 93(1), pp. 130-40. Oxford: Oxford University Press 10.1093/cvr/cvr256

Wyss, Lena; Schäfer, Julia; Liebner, Stefan; Mittelbronn, Michel; Deutsch, Urban; Enzmann, Gaby; Adams, Ralf H.; Aurrand-Lions, Michel; Plate, Karl H.; Imhof, Beat A.; Engelhardt, Britta (2012). Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoS ONE, 7(9), e45619. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0045619

Lyck, Ruth; Engelhardt, Britta (2012). Going against the tide--how encephalitogenic T cells breach the blood-brain barrier. Journal of vascular research, 49(6), pp. 497-509. Basel: Karger 10.1159/000341232

Engelhardt, Britta; Ransohoff, Richard M (2012). Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends in immunology, 33(12), pp. 579-89. Oxford: Elsevier Current Trends 10.1016/j.it.2012.07.004

Ransohoff, Richard M; Engelhardt, Britta (2012). The anatomical and cellular basis of immune surveillance in the central nervous system. Nature reviews - immunology, 12(9), pp. 623-35. London: Nature Publishing Group 10.1038/nri3265

Steiner, Esther; Enzmann, Gaby U; Lin, Shuo; Ghavampour, Sharang; Hannocks, Melanie-Jane; Zuber, Benoît; Rüegg, Markus A; Sorokin, Lydia; Engelhardt, Britta (2012). Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. GLIA, 60(11), pp. 1646-59. Hoboken, N.J.: Wiley-Blackwell 10.1002/glia.22383

Sallusto, Federica; Impellizzieri, Daniela; Basso, Camilla; Laroni, Alice; Uccelli, Antonio; Lanzavecchia, Antonio; Engelhardt, Britta (2012). T-cell trafficking in the central nervous system. Immunological reviews, 248(1), pp. 216-27. Oxford: Wiley-Blackwell 10.1111/j.1600-065X.2012.01140.x

2011

Steiner, Oliver; Coisne, Caroline; Engelhardt, Britta; Lyck, Ruth (2011). Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation. Journal of cerebral blood flow and metabolism, 31(1), pp. 315-27. New York, N.Y.: Nature Publishing Group 10.1038/jcbfm.2010.96

Bill, Ruben; Döring, Axinia; Deutsch, Urban; Engelhardt, Britta (2011). PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice. Journal of neuroimmunology, 232(1-2), pp. 207-8. Amsterdam: Elsevier 10.1016/j.jneuroim.2010.10.008

Lélu, Karine; Laffont, Sophie; Delpy, Laurent; Paulet, Pierre-Emmanuel; Périnat, Therese; Tschanz, Stefan A.; Pelletier, Lucette; Engelhardt, Britta; Guéry, Jean-Charles (2011). Estrogen Receptor α Signaling in T Lymphocytes Is Required for Estradiol-Mediated Inhibition of Th1 and Th17 Cell Differentiation and Protection against Experimental Autoimmune Encephalomyelitis. Journal of immunology, 187(5), pp. 2386-93. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.1101578

Engelhardt, Britta (2011). Neuroscience. Blood-brain barrier differentiation. Science, 334(6063), pp. 1652-3. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1216853

Pfeiffer, Friederike; Schäfer, Julia; Lyck, Ruth; Makrides, Victoria; Brunner, Sarah; Schaeren-Wiemers, Nicole; Deutsch, Urban; Engelhardt, Britta (2011). Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta neuropathologica, 122(5), pp. 601-14. Berlin: Springer-Verlag 10.1007/s00401-011-0883-2

Engelhardt, Britta (2011). β1-integrin/matrix interactions support blood-brain barrier integrity. Journal of cerebral blood flow and metabolism, 31(10), pp. 1969-71. New York, N.Y.: Nature Publishing Group 10.1038/jcbfm.2011.98

Engelhardt, Britta; Coisne, Caroline (2011). Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids and barriers of the CNS, 8(1), p. 4. London: BioMed Central 10.1186/2045-8118-8-4

Döring, Axinia; Pfeiffer, Friederike; Meier, Matthias; Dehouck, Bénédicte; Tauber, Silke; Deutsch, Urban; Engelhardt, Britta (2011). TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis. European journal of immunology, 41(3), pp. 813-21. Weinheim: Wiley-VCH 10.1002/eji.201040912

Coisne, Caroline; Engelhardt, Britta (2011). Tight junctions in brain barriers during central nervous system inflammation. Antioxidants & redox signalling, 15(5), pp. 1285-303. Larchmont, N.Y.: Mary Ann Liebert 10.1089/ars.2011.3929

Greenwood, J; Heasman, S J; Alvarez, J I; Prat, A; Lyck, R; Engelhardt, B (2011). Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain. Neuropathology & applied neurobiology, 37(1), pp. 24-39. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2990.2010.01140.x

Zattoni, Michela; Mura, Maria Luisa; Deprez, Francine; Schwendener, Reto A; Engelhardt, Britta; Frei, Karl; Fritschy, Jean-Marc (2011). Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. Journal of neuroscience, 31(11), pp. 4037-50. Washington, D.C.: Society for Neuroscience 10.1523/JNEUROSCI.6210-10.2011

2010

Boscacci, Rémy T; Pfeiffer, Friederike; Gollmer, Kathrin; Checa Sevilla, Ana Isabel; Martin, Ana Maria; Soriano, Silvia Fernandez; Natale, Daniela; Henrickson, Sarah; von Andrian, Ulrich H; Fukui, Yoshinori; Mellado, Mario; Deutsch, Urban; Engelhardt, Britta; Stein, Jens V (2010). Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood, 116(6), pp. 915-25. Washington, D.C.: American Society of Hematology 10.1182/blood-2009-11-254334

Steiner, Oliver; Coisne, Caroline; Cecchelli, Roméo; Boscacci, Rémy; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth (2010). Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. Journal of immunology, 185(8), pp. 4846-55. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.0903732

Jain, Pooja; Coisne, Caroline; Enzmann, Gaby; Rottapel, Robert; Engelhardt, Britta (2010). Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. Journal of immunology, 184(12), pp. 7196-206. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.0901404

Coisne, Caroline; Engelhardt, Britta (2010). Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo. Methods in molecular biology, 616, pp. 268-281. Totowa, N.J.: Humana Press 10.1007/978-1-60761-461-6_17

Lélu, Karine; Delpy, Laurent; Robert, Virginie; Foulon, Eliane; Laffont, Sophie; Pelletier, Lucette; Engelhardt, Britta; Guéry, Jean-Charles (2010). Endogenous estrogens, through estrogen receptor , constrain autoimmune inflammation in female mice by limiting CD4(+) T-cell homing into the CNS. European journal of immunology, 40(12), pp. 3489-3498. Weinheim: Wiley-VCH 10.1002/eji.201040678

Engelhardt, B.2010 (2010). T cell migration into the CNS during health and disease: Different molecular keys allow access to different CNS compartments. Clinical and experimental neuroimmunology Oxford: Wiley-Blackwell

Engelhardt, Britta (2010). Negotiating the brain barriers: Access of immune cells and pathogens into the CNS. In: Kilpatrick, Trevor; Ransohoff, Richard M; Wesselingh, Steven (eds.) Inflammatory Diseases of the Central Nervous System (pp. 35-46). Cambridge: Cambridge University Press

2009

Rossy, Jérémie; Schlicht, Dominique; Engelhardt, Britta; Niggli, Verena (2009). Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS ONE, 4(4), e5403. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0005403

Engelhardt, Britta (2009). PSGL-1--the hidden player in T cell trafficking into the brain in multiple sclerosis? Journal of leukocyte biology, 86(5), pp. 1023-5. Bethesda, Md.: Society for Leukocyte Biology 10.1189/jlb.0509358

Engelhardt, Britta; Sorokin, Lydia (2009). The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Seminars in immunopathology, 31(4), pp. 497-511. Berlin: Springer-Verlag 10.1007/s00281-009-0177-0

Wolburg-Buchholz, Karen; Mack, Andreas F; Steiner, Esther; Pfeiffer, Friederike; Engelhardt, Britta; Wolburg, Hartwig (2009). Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta neuropathologica, 118(2), pp. 219-33. Berlin: Springer 10.1007/s00401-009-0558-4

Lyck, Ruth; Ruderisch, Nadine; Moll, Anton G; Steiner, Oliver; Cohen, Clemens D; Engelhardt, Britta; Makrides, Victoria; Verrey, Francois (2009). Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo. Journal of cerebral blood flow and metabolism, 29(9), pp. 1491-502. New York, N.Y.: Nature Publishing Group 10.1038/jcbfm.2009.72

Dodelet-Devillers, Aurore; Cayrol, Romain; van Horssen, Jack; Haqqani, Arsalan S; de Vries, Helga E; Engelhardt, Britta; Greenwood, John; Prat, Alexandre (2009). Functions of lipid raft membrane microdomains at the blood-brain barrier. Journal of molecular medicine JMM, 87(8), pp. 765-74. Berlin: Springer 10.1007/s00109-009-0488-6

Coisne, Caroline; Mao, Wenxian; Engelhardt, Britta (2009). Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. Journal of immunology, 182(10), pp. 5909-13. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.0803418

Reboldi, Andrea; Coisne, Caroline; Baumjohann, Dirk; Benvenuto, Federica; Bottinelli, Denise; Lira, Sergio; Uccelli, Antonio; Lanzavecchia, Antonio; Engelhardt, Britta; Sallusto, Federica (2009). C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nature immunology, 10(5), pp. 514-23. New York, N.Y.: Nature Publishing Group 10.1038/ni.1716

Woodfin, Abigail; Voisin, Mathieu-Benoit; Imhof, Beat A; Dejana, Elisabetta; Engelhardt, Britta; Nourshargh, Sussan (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood, 113(24), pp. 6246-57. Washington, D.C.: American Society of Hematology 10.1182/blood-2008-11188375

Bauer, Martina; Brakebusch, Cord; Coisne, Caroline; Sixt, Michael; Wekerle, Hartmut; Engelhardt, Britta; Fässler, Reinhard (2009). Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 106(6), pp. 1920-5. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0808909106

2008

Deutsch, Urban; Schlaeger, Thorsten M; Dehouck, Bénédicte; Döring, Axinia; Tauber, Silke; Risau, Werner; Engelhardt, Britta (2008). Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice. Experimental cell research, 314(6), pp. 1202-16. San Diego, Calif.: Elsevier 10.1016/j.yexcr.2007.12.026

Owens, Trevor; Bechmann, Ingo; Engelhardt, Britta (2008). Perivascular spaces and the two steps to neuroinflammation. Journal of neuropathology and experimental neurology, 67(12), pp. 1113-21. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/NEN.0b013e31818f9ca8

Nottebaum, Astrid F; Cagna, Giuseppe; Winderlich, Mark; Gamp, Alexander C; Linnepe, Ruth; Polaschegg, Christian; Filippova, Kristina; Lyck, Ruth; Engelhardt, Britta; Kamenyeva, Olena; Bixel, Maria Gabriele; Butz, Stefan; Vestweber, Dietmar (2008). VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. Journal of experimental medicine, 205(12), pp. 2929-45. New York, N.Y.: Rockefeller University Press 10.1084/jem.20080406

Linker, Ralf A; Lühder, Fred; Kallen, Karl-Josef; Lee, De-Hyung; Engelhardt, Britta; Rose-John, Stefan; Gold, Ralf (2008). IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier. Journal of neuroimmunology, 205(1-2), pp. 64-72. Amsterdam: Elsevier 10.1016/j.jneuroim.2008.09.007

Schrage, Arnhild; Wechsung, Katja; Neumann, Katrin; Schumann, Michael; Schulzke, Jörg-Dieter; Engelhardt, Britta; Zeitz, Martin; Hamann, Alf; Klugewitz, Katja (2008). Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines. Hepatology, 48(4), pp. 1262-72. Hoboken, N.J.: Wiley Interscience 10.1002/hep.22443

Engelhardt, Britta (2008). The blood-central nervous system barriers actively control immune cell entry into the central nervous system. Current pharmaceutical design, 14(16), pp. 1555-65. Hilversum: Bentham Science Publishers 10.2174/138161208784705432

Uboldi, Chiara; Döring, Axinia; Alt, Carsten; Estess, Pila; Siegelman, Mark; Engelhardt, Britta (2008). L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis. European journal of immunology, 38(8), pp. 2156-67. Weinheim: Wiley-VCH 10.1002/eji.200838209

Pfeiffer, Friederike; Kumar, Varsha; Butz, Stefan; Vestweber, Dietmar; Imhof, Beat A; Stein, Jens V; Engelhardt, Britta (2008). Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node. European journal of immunology, 38(8), pp. 2142-55. Weinheim: Wiley-VCH 10.1002/eji.200838140

Engelhardt, Britta (2008). Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. Journal of the neurological sciences, 274(1-2), pp. 23-6. Amsterdam: Elsevier 10.1016/j.jns.2008.05.019

Sellner, Johann; Greeve, Isabell; Findling, Oliver; Kamm, Christian P.; Minten, Carsten; Engelhardt, Britta; Grandgirard, Denis; Leib, Stephen L.; Mattle, Heinrich P (2008). Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. Neurochemistry international, 53(1-2), pp. 17-21. Amsterdam: Elsevier 10.1016/j.neuint.2008.04.004

Kraus, J; Voigt, K; Schuller, A M; Scholz, M; Kim, K S; Schilling, M; Schäbitz, W R; Oschmann, P; Engelhardt, B (2008). Interferon-beta stabilizes barrier characteristics of the blood-brain barrier in four different species in vitro. Multiple sclerosis journal, 14(6), pp. 843-52. London: Sage 10.1177/1352458508088940

Endres, Matthias; Engelhardt, Britta; Koistinaho, Jari; Lindvall, Olle; Meairs, Stephen; Mohr, Jay P; Planas, Anna; Rothwell, Nancy; Schwaninger, Markus; Schwab, Martin E; Vivien, Denis; Wieloch, Tadeusz; Dirnagl, Ulrich (2008). Improving outcome after stroke: overcoming the translational roadblock. Cerebrovascular diseases, 25(3), pp. 268-78. Basel: Karger 10.1159/000118039

Neuwelt, Edward; Abbott, N Joan; Abrey, Lauren; Banks, William A; Blakley, Brian; Davis, Thomas; Engelhardt, Britta; Grammas, Paula; Nedergaard, Maiken; Nutt, John; Pardridge, William; Rosenberg, Gary A; Smith, Quentin; Drewes, Lester R (2008). Strategies to advance translational research into brain barriers. Lancet neurology, 7(1), pp. 84-96. Oxford: Elsevier 10.1016/S1474-4422(07)70326-5

Engelhardt, Britta; Kappos, Ludwig (2008). Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegenerative diseases, 5(1), pp. 16-22. Basel: Karger 10.1159/000109933

Engelhardt, B. (2008). Adhesion and signalling molecules controlling the extravasation of leukocytes accross the endothelium. Transfusion medicine and hemotherapy, 35(2), pp. 73-75. Basel: Karger 10.1159/000119115

2007

Döring, Axinia; Wild, Martin; Vestweber, Dietmar; Deutsch, Urban; Engelhardt, Britta (2007). E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. Journal of immunology, 179(12), pp. 8470-9. Bethesda, Md.: American Association of Immunologists

Jagasia, Madan; Giglia, Jennifer; Chinratanalab, Wichai; Dixon, Sheri; Chen, Heidi; Frangoul, Haydar; Engelhardt, Brian; Goodman, Stacey; Greer, John; Kassim, Adetola; Morgan, David; Ruffner, Katherine; Schuening, Friedrich (2007). Incidence and outcome of chronic graft-versus-host disease using National Institutes of Health consensus criteria. Biology of blood and marrow transplantation, 13(10), pp. 1207-15. New York, N.Y.: Elsevier 10.1016/j.bbmt.2007.07.001

Engelhardt, Brian G; Holland, Derek W; Brandt, Stephen J; Chinratanalab, Wichai; Goodman, Stacey A; Greer, John P; Jagasia, Madan H; Kassim, Adetola A; Morgan, David S; Ruffner, Katherine L; Schuening, Friedrich G; Wolff, Steven; Bitting, Rhonda; Sulur, Paulgun; Stein, Richard S (2007). High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leukemia & lymphoma, 48(9), pp. 1728-35. London: Informa Healthcare 10.1080/10428190701534374

Klotz, Luisa; Diehl, Linda; Dani, Indra; Neumann, Harald; von Oppen, Nanette; Dolf, Andreas; Endl, Elmar; Klockgether, Thomas; Engelhardt, Britta; Knolle, Percy (2007). Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro. Journal of neuroimmunology, 190(1-2), pp. 34-43. Amsterdam: Elsevier 10.1016/j.jneuroim.2007.07.017

Coisne, Caroline; Lyck, Ruth; Engelhardt, Britta (2007). Therapeutic targeting of leukocyte trafficking across the blood-brain barrier. Inflammation & allergy, drug targets, 6(4), pp. 210-22. Sharjah: Bentham Science Publishers

2006

Engelhardt, Britta (2006). Immune cell migration across the blood–brain barrier: molecular mechanisms and therapeutic targeting. Future neurology, 1(1), 47 - 56. London: Future Medicine Ltd 10.2217/14796708.1.1.47

Engelhardt, Britta (2006). Regulation of immune cell entry into the central nervous system. Results and problems in cell differentiation, 43, pp. 259-280. Berlin: Springer

Wethmar, Klaus; Helmus, Yvonne; Lühn, Kerstin; Jones, Claire; Laskowska, Anna; Varga, Georg; Grabbe, Stephan; Lyck, Ruth; Engelhardt, Britta; Bixel, M Gabriele; Butz, Stefan; Loser, Karin; Beissert, Stefan; Ipe, Ute; Vestweber, Dietmar; Wild, Martin K (2006). Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues. European journal of immunology, 36(10), pp. 2781-94. Weinheim: Wiley-VCH 10.1002/eji.200526311

Hochmeister, Sonja; Grundtner, Roland; Bauer, Jan; Engelhardt, Britta; Lyck, Ruth; Gordon, Grace; Korosec, Thomas; Kutzelnigg, Alexandra; Berger, Johannes J; Bradl, Monika; Bittner, Reginald E; Lassmann, Hans (2006). Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis. Journal of neuropathology and experimental neurology, 65(9), pp. 855-65. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.jnen.0000235119.52311.16

Meairs, Stephen; Wahlgren, Nils; Dirnagl, Ulrich; Lindvall, Olle; Rothwell, Peter; Baron, Jean-Claude; Hossmann, Konstantin; Engelhardt, Britta; Ferro, José; McCulloch, James; Kaste, Markku; Endres, Matthias; Koistinaho, Jari; Planas, Anna; Vivien, Denis; Dijkhuizen, Rick; Czlonkowska, Anna; Hagen, Arne; Evans, Alan; De Libero, Gennaro; ... (2006). Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovascular diseases, 22(2-3), pp. 75-82. Basel: Karger 10.1159/000093098

Engelhardt, B (2006). Molecular mechanisms involved in T cell migration across the blood-brain barrier. Journal of neural transmission, 113(4), pp. 477-85. Wien: Springer 10.1007/s00702-005-0409-y

Walter, Silke; Doering, Axinia; Letiembre, Maryse; Liu, Yang; Hao, Wenlin; Diem, Ricarda; Bernreuther, Christian; Glatzel, Markus; Engelhardt, Britta; Fassbender, Klaus (2006). The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis. Cellular physiology and biochemistry, 17(3-4), pp. 167-72. Basel: Karger 10.1159/000092078

Engelhardt, Britta (2006). Development of the Blood-Brain Interface. In: Dermietzel, Rolf; Spray, David C; Nedergaard, Maiken (eds.) Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (pp. 9-39). Weinheim: Wiley-VCH 10.1002/9783527611225.ch1

Engelhardt, Britta (2006). Physiologie der Blut-Hirn-Schranke – Bedeutung für die Neuroimmunmodulation. In: Straub, Rainer H (ed.) Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 1 (pp. 150-159). Göttingen: Vandenhoeck & Ruprecht V&R unipress

2004

Hamm, Stefan; Dehouck, Bénédicte; Kraus, Jörg; Wolburg-Buchholz, Karen; Wolburg, Hartwig; Risau, Werner; Cecchelli, Roméo; Engelhardt, Britta; Dehouck, Marie-Pierre (2004). Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell and tissue research, 315(2), pp. 157-166. Springer 10.1007/s00441-003-0825-y