· Matti C, D’Uonnolo G, Artinger M, Melgrati S, Salnikov A, Thelen S, Purvanov V, Strobel TD, Spannagel L, Thelen M, Legler DF. 2020. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4. J Leuk Biolin press
· Samson GPB, Legler DF. 2020. Membrane compartimentalization and scaffold proteins in leukocyte migration. Front Cell Dev Biol8:285
· Matti C, Salnikov A, Artinger M, D’Agostino G, Kindinger I, Uguccioni M, Thelen M, Legler DF. 2020. ACKR4 recruits GRK3 prior to β-arrestins but can scavenge chemokines in the absence of β-arrestins. Front Immunol11:720 (2020)
· Laufer JM, Hauser MA, Kindinger I, Purvanov V, Pauli A, Legler DF. 2019. Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation. Cell Rep29(4):995-1009. e6, October 22, 2019.
· Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV. 2019. In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance. J Immunol203(9):2377-2387. doi: 10.4049/jimmunol.1900075. Epub 2019 Sep 23.
· Jørgensen AS, Larsen O, Uetz-von Allmen E, Lückmann M, Legler DF, Frimurer TM, Veldkamp CT, Hjortø GM, Rosenkilde MM. 2019. Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7. Front ImmunolSep 13;10:2156. doi: 10.3389/fimmu.2019.02156. eCollection 2019.
· Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF. 2019. Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7. Int J Mol SciInt J Mol Sci. 2019 May 27;20(10). pii: E2597. doi: 10.3390/ijms20102597.Repository
· Impellizzieri D, Ridder F, Raeber ME, Egholm C, Woytschak J, Kolios AGA, Legler DF, Boyman O. 2019. IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation. J Allergy Clin Immunol144(1):267-279.
· Laufer JM, Kindinger I, Artinger M, Pauli A, Legler DF. 2019. CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70. Front ImmunolJan 14;9:3115. doi: 10.3389/fimmu.2018.03115. eCollection 2018.
· Purvanov V, Matti C, Samson GPB, Kindinger I,Legler DF. 2018. Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions. Int J Mol SciDec 4;19(12). pii: E3876. doi: 10.3390/ijms19123876.
· Rossy J, Laufer JM, Legler DF. 2018. Role of Mechanotransduction and Tension in T Cell Function. Front. Immunol.15 November 2018 | https://doi.org/10.3389/fimmu.2018.02638.
· Jørgensen AS, Adogamhe PE, Laufer JM, Legler DF, Veldkamp CT, Rosenkilde MM, Hjortø GM. 2018. CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells. J Leukoc BiolAug;104(2):401-411. doi: 10.1002/JLB.2VMA0118-008R.
· Laufer JM, Legler DF. 2018. Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions. J Leukoc BiolApr 18. doi: 10.1002/JLB.2MR1217-494R.
· Uetz-von Allmen E, Rippl AV, Farhan H, Legler DF. 2018. A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking. J Leukoc Biol104(2):375-389.Repository
· Laufer JM, Lyck R, Legler DF. 2018. ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins. FASEB JMar 28. doi: 10.1096/fj.201701452RR.
· Thelen M, Legler DF. 2018. Membrane lipid environment: Potential modulation of chemokine receptor function. Cytokinedoi: 10.1016/j.cyto.2018.02.011.
· Legler DF, Thelen M. 2018. New insights in chemokine signaling. F1000ResJan 23;7:95. doi: 10.12688/f1000research.13130.1. eCollection 2018. Review.
· Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Chaucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B. 2017. Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4. FASEB J31:3084-3097.
· Legler DF, Matti C, Laufer JM, Jakobs BD, Purvanov V, Uetz-von Allmen E, Thelen M. 2017. Modulation of chemokine receptor function by cholesterol: new prospects for pharmacological intervention. Mol Pharmacol91:331-338.
· Legler DF, Thelen M. 2016. Chemokines: chemistry, biochemistry and biological function. Chimia70:856-859.
· Weitzenfeld P, Kossover O, Körner C, Meshel T, Wiemann S, Seliktar D, Legler DF, Ben-Baruch A. 2016. Chemokine axes in breast cancer: factors of the tumor microenvironment re-shape the CCR7-driven metastatic spread of luminal-A breast tumors. J Leuk Biol99:1009-1025.
· Hauser MA, Kindinger I, Laufer JM, Späte A-K, Bucher D, Vanes SL, Krueger WA, Wittmann V, Legler DF. 2016. Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses. J Leuk Biol99:993-1007.
· Hauser MA, Schaeuble K, Kindinger I, Impellizzieri D, Krueger WA, Hauck CR, Boyman O, Legler DF. 2016. Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration. ImmunityJan 19;44(1):59-72. doi: 10.1016/j.immuni.2015.12.010.
· Hauser MA, Legler DF. 2016. Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes. J Leukoc Biol99:869-892.
· Schachtner H, Weimershaus M, Stache V, Plewa N, Legler DF, Höpken UE, Maritzen T. 2015. Loss of Gadkin Affects Dendritic Cell Migration In Vitro. PLoS OneDec 1;10(12):e0143883. doi: 10.1371/journal.pone.0143883. eCollection 2015.
· Ackerknecht M, Hauser MA, Legler DF, Stein JV. 2015. In vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity. Front ImmunolJun 8;6:297. doi: 10.3389/fimmu.2015.00297. eCollection 2015.
· Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. 2015. Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Cell Cycle14:1139-1147.
· Maritzen T, Schachtner H, Legler DF. 2015. On the move: Endocytic trafficking in cell migration. Cell Mol Life Sci72(11):2119-2134.
· Tillmann KD, Reiterer V, Baschieri F, Hoffmann J, Millarte V, Hauser MA, Mazza A, Atias N, Legler DF, Sharan R, Weiss M, Farhan H. 2015. Regulation of Sec16 levels and dynamics links proliferation and secretion. J Cell Sci128(4):670-682.
· Legler DF, Uetz-von Allmen E, Hauser MA. 2014. CCR7: Roles in cancer cell dissemination, migration and metastasis formation. Int J Biochem Cell Biol54:78-82.
· Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler DF, Luther SA, Bollenbach T, Sixt M. 2013. Interstitial dendritic cell guidance by haptotactic chemokine gradients.Science339(6117):328-32.
· Bruckner M, Dickel D, Singer E, Legler DF. 2012. Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E2 and liver X receptor activation.Eur J Immunol42(11):2949-2958.
· Schaeuble K, Hauser MA, Rippl AV, Bruderer R, Otero C, Groettrup M, Legler DF. 2012. Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration.J Cell Sci125(19):4463-4474.
· Bruckner M, Dickel D, Singer E, Legler DF. 2012. Distinct modulation of chemokine expression pattern in human monocyte-derived dendritic cells by prostaglandin E2.Cell Immunol276:52-58.
· Schaeuble K, Hauser MA, Singer E, Groettrup M, Legler DF. 2011. Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.J Immunol187(11):5645-52.
· Schumann K, Lämmermann T, Bruckner M, Legler DF, Polleux J, Spatz JP, Schuler G, Förster R, Lutz MB, Sorokin L, Sixt M. 2010. Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity32(5):703-713.
· Legler DF, Bruckner M, Uetz-von Allmen E, Krause P. 2010. Prostaglandin E(2) at new glance: Novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol42(2):198-201.
· Krause P, Bruckner M, Uermosi C, Singer E, Groettrup M, Legler DF. 2009. Prostaglandin E(2) enhances T cell proliferation by inducing the co-stimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells. Blood113(11):2451-2460.
· Otero C, Eisele PS, Schaeuble K, Groettrup M,Legler DF. 2008. Distinct motifs of the chemokine receptor CCR7 regulate signal transduction, receptor trafficking, and chemotaxis. J Cell Sci121:2759-2767.
· Uetz-von Allmen E, Koch M, Fritz G, Legler DF. 2008. V domain of RAGE interacts with AGEs on prostate carcinoma cells. Prostate68:748-758.
· Krause P, Singer E, Darley PI, Klebensberger J, Groettrup M, Legler DF. 2007. Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO. J Leuk Biol82(5):1106-1114.
· Otero C, Groettrup M, Legler DF. 2006. Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation. J Immunol177:2314-2323.
· Langhorst MF, Reuter A, Luxenhofer G, Boneberg EM, Legler DF, Plattner H, Stuermer CAO. 2006. Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells. FASEB J20:711-713, and FASEB J express article online
· Legler DF, Krause P, Scandella E, Singer E, Groettrup M. 2006. Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors. J Immunol176:966-973.
· Stuermer CAO, Langhorst MF, Wiechers M, Legler DF, Hannbeck S, Guse AH, Plattner H. 2004. PrPccapping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction. FASEB J18:1731-1733, and FASEB J express article online
· Legler DF, Johnson-Leger C, Wiedle G, Bron C, Imhof BA. 2004. The αvβ3 integrin as a tumor homing ligand for lymphocytes. EurJ Immunol34:1608-1616.
· Scandella E, Men Y, Legler DF, Gillessen S, Prikler L, Ludewig B, Groettrup, M. 2004. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood103:1595-1601.
· Doucey MA, Legler DF, Faroudi M, Boucheron N, Baumgartner P, Naeher D, Cebecauer M, Hudrisier D, Ruegg C, Palmer E, Valitutti S, Bron C, Luescher IF. 2003. The β1 and β3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation. J Biol Chem278:26983-26991.
· Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C. 2003. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity18:655-664.
· Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M. 2002. Carma1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nat Immunol3:836-843.
· Legler DF, Doucey MA, Cerottini JC, Bron C, Luescher IF. 2001. Selective inhibition of CTL activation by a dipalmitoyl-phospholipid that prevents the recruitment of signaling molecules to lipid rafts. FASEB J15:1601-1603, and FASEB J express article online
· Doucey MA, Legler DF, Boucheron N, Cerottini JC, Bron C, Luescher IF. 2001. CTL activation is induced by cross-linking of TCR/MHC-peptide - CD8/p56Lckadducts in rafts. Eur J Immunol31:1561-1570.
· Legler DF, Wiedle G, Ross FP, Imhof BA. 2001. Superactivation of integrin αvβ3 by low agonist concentrations. J Cell Sci114:1545-1553.
· Wehrli N, Legler DF, Finke D, Toellner KM, Loetscher P, Baggiolini M, Mac-Lennan ICM, Acha-Orbea H. 2001. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes. Eur J Immunol31:609-616.
· Brandes M, Legler DF, Spoerri B, Schaerli P, Moser B. 2000. Activation-dependent modulation of B lymphocyte migration to chemokines. Int Immunol12:1285-1292.
· Arenzana-Seisdedos F, Amara A, Thomas D, Virelizier JL, Baleux F, Clark-Lewis I, Legler DF, Moser B, Baggiolini M. 1998. β-chemokine MDC and HIV-1 infection. Science281:487a.
· Willimann K, Legler DF, Loetscher M, Stuber Roos R, Delgado MB, Clark-Lewis I, Baggiolini M, Moser B. 1998. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur J Immunol28:2025-2034.
· Legler DF, Loetscher M, Stuber Roos R, Clark-Lewis I, Baggiolini M, Moser B. 1998. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med187:655-660.
· Loetscher M, Amara A, Oberlin E, Brass N, Legler DF, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B. 1997. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol7:652-660.
· Stuber Roos R, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. 1997. Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem272:17251-17254.
· Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature382:833-835.
