2024
Berve, Kristina; Michel, Julia; Tietz, Silvia; Blatti, Claudia; Ivan, Daniela; Enzmann, Gaby; Lyck, Ruth; Deutsch, Urban; Locatelli, Giuseppe; Engelhardt, Britta
(2024).
Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis.
European journal of immunology, 54(6), e2350761.
Wiley-VCH
10.1002/eji.202350761
2023
Saltarin, Federico; Wegmüller, Adrian; Bejarano, Leire; Ildiz, Eco Su; Zwicky, Pascale; Vianin, Andréj; Spadin, Florentin; Soukup, Klara; Wischnewski, Vladimir; Engelhardt, Britta; Deutsch, Urban; Marques, Ines J.; Frenz, Martin; Joyce, Johanna A.; Lyck, Ruth
(2023).
Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation.
Cancers, 15(20), p. 5071.
MDPI AG
10.3390/cancers15205071
Lyck, Ruth; Nishihara, Hideaki; Aydin, Sidar; Soldati, Sasha; Engelhardt, Britta
(2023).
Modeling Brain Vasculature Immune Interactions In Vitro.
Cold Spring Harbor perspectives in medicine, 13(9), a041185.
Cold Spring Harbor Laboratory Press
10.1101/cshperspect.a041185
2022
Lorusso, Girieca; Wyss, Christof B; Kuonen, François; Vannini, Nicola; Billottet, Clotilde; Duffey, Nathalie; Pineau, Raphael; Lan, Qiang; Wirapati, Pratyaksha; Barras, David; Tancredi, Alessandro; Lyck, Ruth; Lehr, Hans-Anton; Engelhardt, Britta; Delorenzi, Mauro; Bikfalvi, Andreas; Rüegg, Curzio
(2022).
Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.
Science translational medicine, 14(661), eaax8933.
American Association for the Advancement of Science
10.1126/scitranslmed.aax8933
Dzung, Andreas; Saltari, Annalisa; Tiso, Natascia; Lyck, Ruth; Dummer, Reinhard; Levesque, Mitchell P
(2022).
STK11 Prevents Invasion Through STAT3/5 and FAK Repression in Cutaneous Melanoma.
Journal of investigative dermatology, 142(4), 1171-1182.e10.
Elsevier
10.1016/j.jid.2021.09.035
Marchetti, Luca; Francisco, David; Soldati, Sasha; Haghayegh Jahromi, Neda; Barcos, Sara; Gruber, Isabelle; Pareja R., Javier; Thiriot, Aude; von Andrian, Ulrich; Deutsch, Urban; Lyck, Ruth; Bruggmann, Rémy; Engelhardt, Britta
(2022).
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
European journal of immunology, 52(1), pp. 161-177.
Wiley
10.1002/eji.202149238
2021
Hamminger, Patricia; Marchetti, Luca; Preglej, Teresa; Platzer, René; Zhu, Ci; Kamnev, Anton; Rica, Ramona; Stolz, Valentina; Sandner, Lisa; Alteneder, Marlis; Kaba, Elisa; Waltenberger, Darina; Huppa, Johannes B; Trauner, Michael; Bock, Christoph; Lyck, Ruth; Bauer, Jan; Dupré, Loïc; Seiser, Christian; Boucheron, Nicole; ...
(2021).
Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases.
Journal of autoimmunity, 119, p. 102610.
Elsevier
10.1016/j.jaut.2021.102610
Vizcaino, Josue Page; Saltarin, Federico; Belyaev, Yury; Lyck, Ruth; Lasser, Tobias; Favaro, Paolo
(2021).
Learning to Reconstruct Confocal Microscopy Stacks From Single Light Field Images.
IEEE transactions on computational imaging, 7, pp. 775-788.
IEEE
10.1109/TCI.2021.3097611
2019
Castro Dias, Mariana; Coisne, Caroline; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Ferreira Francisco, David Miguel; Vanlandewijck, Michael; He, Liqun; Baier, Felix A.; Stroka, Deborah; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta
(2019).
Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers.
Scientific reports, 9(1), p. 10702.
Springer Nature
10.1038/s41598-019-43511-0
Mota Castro Dias, Mariana; Coisne, Caroline Marie; Lazarevic, Ivana; Baden, Pascale; Hata, Masaki; Iwamoto, Noriko; Francisco, David Miguel Ferreira; Vanlandewijck, Michael; He, Liqun; Baier, Felix Alexander; Keogh-Stroka, Deborah M.; Bruggmann, Rémy; Lyck, Ruth; Enzmann, Gaby; Deutsch, Urban; Betsholtz, Christer; Furuse, Mikio; Tsukita, Shoichiro; Engelhardt, Britta
(2019).
Claudin-3-deficient C57BL/6J mice display intact brain barriers.
Scientific Reports, 9(1), p. 203.
Nature Publishing Group
10.1038/s41598-018-36731-3
Wimmer, Isabella; Tietz, Silvia; Nishihara, Hideaki; Deutsch, Urban; Sallusto, Federica; Gosselet, Fabien; Lyck, Ruth; Muller, William A; Lassmann, Hans; Engelhardt, Britta
(2019).
PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.
Frontiers in immunology, 10, p. 711.
Frontiers Research Foundation
10.3389/fimmu.2019.00711
2018
Lamas-Murua, Miguel; Stolp, Bettina; Kaw, Sheetal; Thoma, Judith; Tsopoulidis, Nikolaos; Trautz, Birthe; Ambiel, Ina; Reif, Tatjana; Arora, Sakshi; Imle, Andrea; Tibroni, Nadine; Wu, Jingxia; Cui, Guoliang; Stein, Jens Volker; Tanaka, Motomu; Lyck, Ruth; Fackler, Oliver T
(2018).
HIV-1 Nef Disrupts CD4 T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface.
Journal of immunology, 201(9), pp. 2731-2743.
American Association of Immunologists
10.4049/jimmunol.1701420
Laufer, Julia M; Lyck, Ruth; Legler, Daniel F
(2018).
ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins.
FASEB journal, 32(9), pp. 4824-4835.
Federation of American Societies for Experimental Biology
10.1096/fj.201701452RR
Moalli, Federica; Ficht, Xenia; Germann, Philipp; Vladymyrov, Mykhailo; Stolp, Bettina; de Vries, Ingrid; Lyck, Ruth; Balmer, Jasmin Maria; Fiocchi, Amleto; Kreutzfeldt, Mario; Merkler, Doron; Iannacone, Matteo; Ariga, Akitaka; Stoffel, Michael Hubert; Sharpe, James; Bähler, Martin; Sixt, Michael; Diz-Muñoz, Alba; Stein, Jens Volker
(2018).
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells.
Journal of experimental medicine, 215(7), pp. 1869-1890.
Rockefeller University Press
10.1084/jem.20170896
García-Martín, Ana B; Zwicky, Pascale; Gruber, Thomas; Matti, Christoph; Moalli, Federica; Stein, Jens Volker; Francisco, David; Enzmann, Gaby; Levesque, Mitchell P; Hewer, Ekkehard; Lyck, Ruth
(2018).
VLA-4 mediated adhesion of melanoma cells on the blood-brain barrier is the critical cue for melanoma cell intercalation and barrier disruption.
Journal of cerebral blood flow and metabolism, 39(10), pp. 1995-2010.
Sage
10.1177/0271678X18775887
2017
Mager, Lukas Franz; Kölzer, Viktor Hendrik; Stuber Roos, Regula; Thoo Sin Lang, Lester; Keller, Irene; Köck, Ivonne; Langenegger, Maya; Simillion, Cedric; Pfister, Simona P; Faderl, Martin Richard; Genitsch Gratwohl, Vera; Tcymbarevich, Irina; Juillerat, Pascal; Li, Xiaohong; Xia, Yu; Karamitopoulou, Evanthia; Lyck, Ruth; Zlobec, Inti; Hapfelmeier, Siegfried Hektor; Bruggmann, Rémy; ...
(2017).
The ESRP1-GPR137 axis contributes to intestinal pathogenesis.
eLife, 6
eLife Sciences Publications
10.7554/eLife.28366
Lyck, Ruth; Lécuyer, Marc-André; Abadier, Michael Magdy Labib; Wyss, Christof B.; Matti, Christoph; Rosito, Maria; Enzmann, Gaby; Zeis, Thomas; Michel, Laure; García Martín, Ana B; Sallusto, Federica; Gosselet, Fabien; Deutsch, Urban; Weiner, Joshua A.; Schaeren-Wiemers, Nicole; Prat, Alexandres; Engelhardt, Britta
(2017).
ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier.
Journal of cerebral blood flow and metabolism, 37(8), pp. 2894-2909.
Nature Publishing Group
10.1177/0271678X16678639
Moore, Thomas L; Hauser, Daniel; Gruber, Thomas; Rothen-Rutishauser, Barbara; Lattuada, Marco; Petri-Fink, Alke; Lyck, Ruth
(2017).
Cellular Shuttles: Monocytes/Macrophages Exhibit Transendothelial Transport of Nanoparticles under Physiological Flow.
ACS applied materials & interfaces, 9(22), pp. 18501-18511.
American Chemical Society
10.1021/acsami.7b03479
Lécuyer, Marc-André; Saint-Laurent, Olivia; Bourbonnière, Lyne; Larouche, Sandra; Larochelle, Catherine; Michel, Laure; Charabati, Marc; Abadier, Michael Magdy Labib; Zandee, Stephanie; Haghayegh Jahromi, Neda; Gowing, Elizabeth; Pittet, Camille; Lyck, Ruth; Engelhardt, Britta; Prat, Alexandre
(2017).
Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(4), E524-E533.
National Academy of Sciences NAS
10.1073/pnas.1614336114
Köchl, Robert; Thelen, Flavian; Vanes, Lesley; Brazão, Tiago F; Fountain, Kathryn; Xie, Jian; Huang, Chou-Long; Lyck, Ruth; Stein, Jens Volker; Tybulewicz, Victor L J
(2017).
Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo.
Nature immunology, 18(2), p. 246.
Nature Publishing Group
10.1038/ni0217-246a
Abadier, Michael Magdy Labib; Lyck, Ruth
(2017).
Pathways across the blood-brain barrier.
In:
Lyck, Ruth; Enzmann, Gaby
(eds.)
The Blood Brain Barrier and Inflammation. Progress in Inflammation Research (pp. 187-211).
Springer
10.1007/978-3-319-45514-3_9
2016
Köchl, Robert; Thelen, Flavian; Vanes, Lesley; Brazão, Tiago F; Fountain, Kathryn; Xie, Jian; Huang, Chou-Long; Lyck, Ruth; Stein, Jens Volker; Tybulewicz, Victor L J
(2016).
WNK1 kinase balances T cell adhesion versus migration in vivo.
Nature immunology, 17(9), pp. 1075-1083.
Nature Publishing Group
10.1038/ni.3495
Rudolph, Henriette; Klopstein, Armelle; Gruber, Isabelle Manuela; Blatti, Claudia; Lyck, Ruth; Engelhardt, Britta
(2016).
Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro.
European journal of immunology, 46(9), pp. 2187-2203.
Wiley-VCH
10.1002/eji.201546251
Imeri, Faik; Schwalm, Stephanie; Lyck, Ruth; Zivkovic, Aleksandra; Stark, Holger; Engelhardt, Britta; Pfeilschifter, Josef; Huwiler, Andrea
(2016).
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Neuropharmacology, 105, pp. 341-350.
Elsevier
10.1016/j.neuropharm.2016.01.031
Lopes Pinheiro, Melissa A; Kooij, Gijs; Mizee, Mark R; Kamermans, Alwin; Enzmann, Gaby; Lyck, Ruth; Schwaninger, Markus; Engelhardt, Britta; de Vries, Helga E
(2016).
Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.
Biochimica et biophysica acta - molecular basis of disease, 1862(3), pp. 461-471.
Elsevier
10.1016/j.bbadis.2015.10.018
2015
Abadier, Michael Magdy Labib; Haghayegh Jahromi, Neda; Cardoso Alves, Ludmila; Boscacci, Rémy; Vestweber, Dietmar; Barnum, Scott; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth
(2015).
Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier.
European journal of immunology, 45(4), pp. 1043-1058.
Wiley-VCH
10.1002/eji.201445125
Lyck, Ruth; Enzmann, Gaby
(2015).
The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues.
Current opinion in hematology, 22(1), pp. 53-59.
Wolters Kluwer Lippincott Williams & Wilkins
10.1097/MOH.0000000000000103
2014
Steiner, Esther; Enzmann, Gaby; Lyck, Ruth; Lin, Shuo; Rüegg, Markus A; Kröger, Stephan; Engelhardt, Britta
(2014).
The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.
Cell and tissue research, 358(2), pp. 465-479.
Springer
10.1007/s00441-014-1969-7
Gorina Mendiz, Roser; Lyck, Ruth; Vestweber, Dietmar; Engelhardt, Britta
(2014).
β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.
Journal of immunology, 192(1), pp. 324-337.
American Association of Immunologists
10.4049/jimmunol.1300858
Minten, Carsten; Alt, Carsten; Gentner, Melanie; Frei, Elisabeth; Deutsch, Urban; Lyck, Ruth; Schaeren-Wiemers, Nicole; Rot, Antal; Engelhardt, Britta
(2014).
DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.
Brain, 137(Pt 5), pp. 1454-1469.
Oxford University Press
10.1093/brain/awu045
2013
Moretti, Federico A.; Moser, Markus; Lyck, Ruth; Abadier, Michael Magdy Labib; Ruppert, Raphael; Engelhardt, Britta; Fässler, Reinhard
(2013).
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 110(42), pp. 17005-17010.
National Academy of Sciences NAS
10.1073/pnas.1316032110
Martinelli, Sibylla; Chen, Emily J. H.; Clarke, Fiona; Lyck, Ruth; Affentranger, Sarah; Burkhardt, Janis K.; Niggli, Verena
(2013).
Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cells.
Frontiers in immunology, 4, p. 84.
Frontiers Research Foundation
10.3389/fimmu.2013.00084
2012
Nitschké, Maximilian; Aebischer, David; Abadier, Michael Magdy Labib; Haener, Simone; Lucic, Matije; Vigl, Benjamin; Luche, Hervé; Fehling, Hans Jörg; Biehlmaier, Oliver; Lyck, Ruth; Halin, Cornelia
(2012).
Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation.
Blood, 120(11), pp. 2249-58.
Washington, D.C.: American Society of Hematology
10.1182/blood-2012-03-417923
Stolp, Bettina; Imle, Andrea; Coelho, Fernanda Matos; Hons, Miroslav; Gorina, Roser; Lyck, Ruth; Stein, Jens V; Fackler, Oliver T
(2012).
HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 109(45), pp. 18541-6.
Washington, D.C.: National Academy of Sciences NAS
10.1073/pnas.1204322109
Lyck, Ruth; Engelhardt, Britta
(2012).
Going against the tide--how encephalitogenic T cells breach the blood-brain barrier.
Journal of vascular research, 49(6), pp. 497-509.
Basel: Karger
10.1159/000341232
2011
Steiner, Oliver; Coisne, Caroline; Engelhardt, Britta; Lyck, Ruth
(2011).
Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.
Journal of cerebral blood flow and metabolism, 31(1), pp. 315-27.
New York, N.Y.: Nature Publishing Group
10.1038/jcbfm.2010.96
Brun-Heath, Isabelle; Ermonval, Myriam; Chabrol, Elodie; Xiao, Jinsong; Palkovits, Miklós; Lyck, Ruth; Miller, Florence; Couraud, Pierre-Olivier; Mornet, Etienne; Fonta, Caroline
(2011).
Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues.
Cell and tissue research, 343(3), pp. 521-36.
Heidelberg: Springer
10.1007/s00441-010-1111-4
Pfeiffer, Friederike; Schäfer, Julia; Lyck, Ruth; Makrides, Victoria; Brunner, Sarah; Schaeren-Wiemers, Nicole; Deutsch, Urban; Engelhardt, Britta
(2011).
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Acta neuropathologica, 122(5), pp. 601-14.
Berlin: Springer-Verlag
10.1007/s00401-011-0883-2
Greenwood, J; Heasman, S J; Alvarez, J I; Prat, A; Lyck, R; Engelhardt, B
(2011).
Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain.
Neuropathology & applied neurobiology, 37(1), pp. 24-39.
Oxford: Blackwell Scientific Publications
10.1111/j.1365-2990.2010.01140.x
Soriano, Silvia F; Hons, Miroslav; Schumann, Kathrin; Kumar, Varsha; Dennier, Timo J; Lyck, Ruth; Sixt, Michael; Stein, Jens V
(2011).
In vivo analysis of uropod function during physiological T cell trafficking.
Journal of immunology, 187(5), pp. 2356-64.
Bethesda, Md.: American Association of Immunologists
10.4049/jimmunol.1100935
2010
Steiner, Oliver; Coisne, Caroline; Cecchelli, Roméo; Boscacci, Rémy; Deutsch, Urban; Engelhardt, Britta; Lyck, Ruth
(2010).
Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium.
Journal of immunology, 185(8), pp. 4846-55.
Bethesda, Md.: American Association of Immunologists
10.4049/jimmunol.0903732
Faroudi, Mustapha; Hons, Miroslav; Zachacz, Agnieszka; Dumont, Celine; Lyck, Ruth; Stein, Jens V; Tybulewicz, Victor L J
(2010).
Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.
Blood, 116(25), pp. 5536-47.
Washington, D.C.: American Society of Hematology
10.1182/blood-2010-08-299438
2009
Lyck, Ruth; Ruderisch, Nadine; Moll, Anton G; Steiner, Oliver; Cohen, Clemens D; Engelhardt, Britta; Makrides, Victoria; Verrey, Francois
(2009).
Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo.
Journal of cerebral blood flow and metabolism, 29(9), pp. 1491-502.
New York, N.Y.: Nature Publishing Group
10.1038/jcbfm.2009.72
2008
Nottebaum, Astrid F; Cagna, Giuseppe; Winderlich, Mark; Gamp, Alexander C; Linnepe, Ruth; Polaschegg, Christian; Filippova, Kristina; Lyck, Ruth; Engelhardt, Britta; Kamenyeva, Olena; Bixel, Maria Gabriele; Butz, Stefan; Vestweber, Dietmar
(2008).
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.
Journal of experimental medicine, 205(12), pp. 2929-45.
New York, N.Y.: Rockefeller University Press
10.1084/jem.20080406
2007
Coisne, Caroline; Lyck, Ruth; Engelhardt, Britta
(2007).
Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.
Inflammation & allergy, drug targets, 6(4), pp. 210-22.
Sharjah: Bentham Science Publishers
2006
Wethmar, Klaus; Helmus, Yvonne; Lühn, Kerstin; Jones, Claire; Laskowska, Anna; Varga, Georg; Grabbe, Stephan; Lyck, Ruth; Engelhardt, Britta; Bixel, M Gabriele; Butz, Stefan; Loser, Karin; Beissert, Stefan; Ipe, Ute; Vestweber, Dietmar; Wild, Martin K
(2006).
Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues.
European journal of immunology, 36(10), pp. 2781-94.
Weinheim: Wiley-VCH
10.1002/eji.200526311
Hochmeister, Sonja; Grundtner, Roland; Bauer, Jan; Engelhardt, Britta; Lyck, Ruth; Gordon, Grace; Korosec, Thomas; Kutzelnigg, Alexandra; Berger, Johannes J; Bradl, Monika; Bittner, Reginald E; Lassmann, Hans
(2006).
Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis.
Journal of neuropathology and experimental neurology, 65(9), pp. 855-65.
Hagerstown, Md.: Lippincott Williams & Wilkins
10.1097/01.jnen.0000235119.52311.16
